I never had the problem of having a locked folder access.. Even when I couldn't uninstall a program/file... I usually just delete the whole folder in program files list (if it's tied to a process, I can end the process in the Task manager). Or the one time I gave myself permission to access to read/write/view the file in properties. But never has permission issue since I am the only one using the computer
I only know Fileassassin from Malwarebytes.. It basically terminates the folder's process and allows it to be deleted by the user. Which is the same functionality of Unlocker